Linear and Skeletal growth (Primary action). rHGH acts through specific growth hormone receptors which are present in chondrocytes, osteobalsts, hepatocytes, adiocytes and fibrolblasts. These receptors are also found in other tissues such as the brain and gastrointestinal track where the role of growth hormone is not clear.
Growth Hormone stimulates skeletal and soft tissue growth by promoting cell division, amino acids uptake and protein synthesis. Its actions are predominantly mediated by hepatitis and peripheral insulin-like growth factor-1 (IGF-1) production. This results in:
• Skeletal growth in pediatric patients with growth hormone deficiency by its effect on the epiphyseal growth plates of long bones. There is an increasing growth rate and IGF-1 levels similar to that seen with human growth hormone.
• Increase in the number and size of muscle cells.
• Increase in internal organ size and red cell mass.
• Increased cellular protein synthesis due to nitrogen retention leading to a positive nitrogen balance as demonstrated by decline in urinary nitrogen excretion and blood urea nitrogen (BUN).
Carbohydrate metabolism. Genheal™ actions are predominantly mediated by hepatic and peripheral insulin-like growth factor-1 (IGF-1) production leading to immediate but brief insulin-like actions followed by more significant anti-insulin-like effects which include decreased glucose utilization (hyperglycemia) and lipolysis within 2-4 hours.